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A 2017 review noted that this peptide has reduced the appearance of wrinkles by around 12% in human subjects, and when combined with acetyl hexapeptide-8, it can be used to extend the anti-wrinkle effects of Botox injections.32 Syn-Ake In a recent 2024 study examining in silico and in vitro tests, Syn-Ake displayed antioxidant capabilities, meaning it could help scavenge free radicals and prevent them from damaging or aging skin.33 Additionally, a 2024 review explained that the peptide may prevent the uptake of sodium ions in muscles, keeping them relaxed and reducing the risk of developing wrinkles

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