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10.1111/acel.14184 70 HarunaY.KashiharaN.SatohM.TomitaN.NamikoshiT.SasakiT.et al (2007)
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Mechanisms of Muscle Hypertrophy IGF-1 DES promotes muscle growth through potent activation of IGF-1 receptors on muscle cells, triggering PI3K/Akt/mTOR pathways mediating protein synthesis, increased amino acid and glucose uptake into myocytes, satellite cell activation and proliferation, inhibition of protein degradation (anti-catabolic effects), and enhanced muscle fiber hypertrophy
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