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In addition to being an amino acid, glutamate is a neurotransmitter³³, the major excitatory neurotransmitter of the vertebrate central nervous system.⁴ ³⁴ Glutamate in the brain is either synthesized in the brain or obtained from the recycling of brain proteins.²⁶ ³⁵ Levels of glutamate in the brain (10,000–12,000 µM) are at least 100 times higher than circulating blood levels (50–100 µM).²⁶ Because of the blood-brain barrier (which prevents many substances in the bloodstream from entering the brain), levels of glutamate in the blood do not affect levels of glutamate in the brain.²⁶ ³⁵ Under certain pathological conditions (e.g., ischemic stroke), release of glutamate from brain cells can occur, leading to extreme excitation of nerve cells