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The rise in NAD(P)H levels correlated with enhancement of glucose-stimulated insulin secretion, glycolysis (as demonstrated by elevated levels of G-6-P and F-6-P), and mitochondrial respiration (as demonstrated by increases in glucose oxidation, oxygen consumption, ATP production, and the TCA cycle intermediate metabolites citrate, malate, and fumarate) (86)

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Since then, emerging evidence is slowly consolidating the anti-proliferative effects of curcumin on primary brain tumor progression